The reference site for Metoprolol

Metoprolol, marketed under the tradename Lopressor among others, is a medication of the selective β1 receptor blocker type.

WHAT IS Metoprolol?

Metoprolol is in a class of medications called beta blockers. It works by slowing the heart rate and relaxing the blood vessels so the heart does not have to pump as hard.

This medication is used alone or in combination with other medications to treat high blood pressure, to prevent angina (chest pain) and to treat heart attacks. Moreover, extended-release (long-acting) metoprolol is also used in combination with other medications to treat heart failure.

It is marketed under the brand name Lopresor® by Novartis, and Toprol® (in the USA), Seleken® or Selokeen® (elsewhere), Betaloc® by AstraZeneca, and as Corvitol® by Berlin-Chemie AG. Generic brands marketed in the Australasian region include Minax® by Alphapharm, Metrol® by Arrow and Metohexal® under Hexal.


Brand Name(s): Lopressor; Toprol XL

CAS nº: 37350-58-6

(me toe’ proe lole)


Product Info

The sections below will provide you with more specific information and guidelines related to metropolol and its correct use. Please read them carefully.

FDA Information

Metropolol has been approved by the U.S. Food and Drug Administration (FDA).

Mylan Laboratories, Inc., announced that the FDA has granted final approval for Mylan Pharmaceuticals’ abbreviated new drug application, which provides for a new strength (25 mg) of metoprolol tartrate (a beta blocker).

President and COO Louis J. DeBone stated, “Mylan is the single largest generic supplier of metoprolol tartrate, in 50-mg and 100-mg strengths, in the United States. The addition of a new 25-mg strength further enhances our generic product portfolio and offers a convenient dosage alternative for patients and healthcare providers.”

Please visit the official site of the FDA for further information.

Why is this medication prescribed?

Metoprolol is prescribed for several symptoms, including patients with high blood pressure (hypertension), to treat chest pain (angina pectoris) related to coronary artery disease, and is also useful in slowing and regulating certain types of abnormally rapid heart rates (tachycardias).

Metoprolol is a beta-adrenergic blocking agent, and works by blocking the action of the sympathetic nervous system, a portion of the involuntary nervous system. The sympathetic nervous system stimulates the pace of the heart beat. By blocking the action of these nerves, metoprolol reduces the heart rate and is useful in treating abnormally rapid heart rhythms. Metoprolol also reduces the force of heart muscle contraction and lowers blood pressure. By reducing the heart rate and the force of muscle contraction, metoprolol reduces heart muscle oxygen demand. Since angina occurs when oxygen demand of the heart exceeds supply, metoprolol is helpful in treating angina.

Other uses for this medicine

Metoprolol has also been used on ocassions to prevent migraine headaches and to treat irregular heartbeat and movement disorders caused by medications for mental illness.

However, it is important that you talk to your doctor about the possible risks of using this drug for your particular condition.

Dosage and using this medicine

Metoprolol comes as a tablet and an extended-release tablet to be taken orally. The regular tablet is usually taken once or twice a day with meals or immediately after meals. The extended-release tablet is usually taken once a day.

To help you remember to take metoprolol, take it around the same time every day.

Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Moreover, do not take more or less of it or take it more often than prescribed by your doctor.

The long-acting tablet may be split. Swallow the whole or half tablets whole, and do not chew or crush them.

Your doctor may start you on a low dose of metoprolol and gradually increase your dose.

Please note that metoprolol controls high blood pressure and angina but does not cure them. So too, the extended-release metoprolol controls heart failure but does not cure it. It may take a few weeks before you feel the full benefit of metoprolol, and until you speak with your doctor you should continue to take metoprolol even if you feel well.

What special precautions should I follow?


Please tell your doctor and pharmacist if you are allergic to metoprolol or any other medications.

Inform your doctor and pharmacist what prescription and non-prescription medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention any of the following: fluoxetine (Prozac®, Sarafem®); paroxetine (Paxil®); propafenone (Rythmol®); quinidine (Quinidex®); and reserpine (Serpalan®, Serpasil®, Serpatab®). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

Furthermore, you should let your doctor know if you have or have ever had asthma or other lung disease, a slow heart rate, heart or liver disease, diabetes, or an overactive thyroid gland (hyperthyroidism).

Tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking metoprolol, call your doctor.

If you are having surgery, including dental surgery, you should inform the doctor or dentist that you are taking metoprolol.

This medication may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you. Additionally, alcohol can add to the drowsiness caused by this medication.

NOTICE: You should know that if you have allergic reactions to different substances, your reactions may be worse while you are using metoprolol, and your allergic reactions may not respond to the usual doses of injectable epinephrine.

What should I do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule.

Never take a double dose to make up for a missed one.

What side effects can this medication cause?

Possible side effects from metoprolol may include:

decreased sex drive, impotence, or difficulty having an orgasm
sleep problems (insomnia)
tired feeling
anxiety, nervousness

Tell your doctor if any of these symptoms are severe or do not go away:

dizziness or lightheadedness
upset stomach
dry mouth
stomach pain
gas or bloating
rash or itching
cold hands and feet

Additionally, if you experience any of the following symptoms, call your doctor immediately:

shortness of breath or wheezing
swelling of the hands, feet, ankles, or lower legs
unusual weight gain
rapid, pounding, or irregular heartbeat

Metoprolol may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

What storage conditions are needed for this medicine?

Always keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is advised that you throw away any medication that is outdated or no longer needed. If you have any questions, please talk to your pharmacist about the proper disposal of your medication.

In case of an emergency/overdose

In the case of an overdose, call your local poison control center on 1-800-222-1222. However, if the victim has collapsed or is not breathing, please call the local emergency services immediately on 911.

Symptoms of a metoprolol overdose may include:

difficulty breathing or swallowing
swelling of the hands, feet, ankles, or lower legs

Product Images


Below you will find images and specific information on the principal types of metoprolol that exist, including their respective brand name(s), strength, inscription codes and manufacturers.

The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.


Strength(s): 50 MG
Imprint: A MO
Manufacturer: ASTRAZENECA

Strength(s): 50 MG
Imprint: GEIGY | 51 51
Manufacturer: NOVARTIS

Strength(s): 50 MG
Imprint: M 32
Manufacturer: MYLAN

Strength(s): 50 MG
Imprint: MP 184
Manufacturer: MUTUAL PHARM.

Strength(s): 50 MG
Imprint: GG 414
Manufacturer: GENEVA

Strength(s): 50/25 MG
Imprint: 35 35 | GEIGY
Manufacturer: NOVARTIS

Strength(s): 100 MG
Imprint: GEIGY | 71 71
Manufacturer: NOVARTIS

Strength(s): 100 MG
Imprint: GG 415
Manufacturer: GENEVA

Strength(s): 100 MG
Imprint: M 47
Manufacturer: MYLAN

Strength(s): 100 MG
Imprint: 9.3 734
Manufacturer: TEVA USA

Strength(s): 100 MG
Imprint: WATSON 463
Manufacturer: WATSON LABS.

Strength(s): 100 MG
Imprint: A MS
Manufacturer: ASTRAZENECA

Strength(s): 100/25 MG
Imprint: M 434
Manufacturer: MYLAN

Strength(s): 100/50 MG
Imprint: 73 73 | GEIGY
Manufacturer: NOVARTIS

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